tag:blogger.com,1999:blog-5271047220330761057.post2168191392735399634..comments2023-08-17T09:07:47.757-07:00Comments on Wellness for the World: The Hormone TrilogyGlen Depke of Depke Wellnesshttp://www.blogger.com/profile/06172459744378973409noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-5271047220330761057.post-84702474945987232052014-08-05T18:31:37.677-07:002014-08-05T18:31:37.677-07:00You are correct with your assumption.
Call the of...You are correct with your assumption.<br /><br />Call the office at (949)954-6226 and set up a complimentary 20 minute new client phone consult.<br /><br />You're welcome!Glen Depke of Depke Wellnesshttps://www.blogger.com/profile/06172459744378973409noreply@blogger.comtag:blogger.com,1999:blog-5271047220330761057.post-50890901731017371862014-08-05T06:58:44.300-07:002014-08-05T06:58:44.300-07:00Thank you Glen! So I assume in this scenario the ...Thank you Glen! So I assume in this scenario the endometriosis (however it got started) would continue this feedback loop as well. Guess the next question is - how to fix this! Better give you guys a call! Thanks again.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5271047220330761057.post-55881540563121978232014-08-01T19:04:58.126-07:002014-08-01T19:04:58.126-07:00Very good! Could not have said it better myself. I...Very good! Could not have said it better myself. I would only add that other triggers for adrenal insufficiency are food sensitivities, inflammation and infection.Glen Depke of Depke Wellnesshttps://www.blogger.com/profile/06172459744378973409noreply@blogger.comtag:blogger.com,1999:blog-5271047220330761057.post-41782064739263284162014-07-30T16:47:39.081-07:002014-07-30T16:47:39.081-07:00Glen - this post was a serious light-bulb moment f...Glen - this post was a serious light-bulb moment for me as I wasn't aware of the effects of insulin on Aromatase. I think I finally have all of the pieces put together. Can you review this and let me know if I've figured out the puzzle?<br /><br />This is in the context of a woman who has both PCOS and Endometriosis:<br /><br />1. You experience ongoing mental and physical stress.<br />2. Your body produces cortisol and adrenaline in response to that stress.<br />3. The more cortisol you need, the more cholesterol you need to produce it (Cholesterol -> 17OH Pregnenonlone - > 17a OH – Progesterone. <br />4. Your cholesterol increases, especially and unfortunately, your LDL cholesterol. <br />5. This same pathway also depletes your progesterone. Progesterone also drops in perimenopausal and menopausal women when ovarian function diminishes.<br />6. The cortisol released from the adrenal glands raises glucose levels, which crash and peak, crash and peak, creating inflammation and cravings.<br />7. You eat sugary and carbohydrate loaded foods to trigger a release of serotonin, a feel-good chemical, in the brain and to raise blood sugars again in response to the cortisol.<br />8. Your body is in an elevated state of insulin from both a) elevated cortisol and b) the carbohydrates you ingest.<br />9. Your body becomes “insulin resistant” over time because of this constant peak/crash, driving blood sugars higher and higher.<br />10. Your blood sugar and insulin levels rise to pre-diabetic or diabetic levels.<br />11. Aromatase is stimulated by elevated insulin; the more resistant you are, the more insulin your body releases into your system, leading to more Aromatase activity in your body, especially the sensitive cells of the endometrium.<br />12. Patients with Endometriosis are known to have aberrant Aromatase in their endometrium (normal controls do not).<br />13. Aromatase in the endometrium converts testosterone to Estradiol (bad) and prevents the conversion of Estradiol (bad) to Estrone (good).<br />14. Localized estrogen dominance occurs, even in the absence of high circulating estrogens in serum, urine or saliva.<br />15. The endometrium thickens wherever the localized aromatization occurs. This becomes hyperplasia without atypia (initially).<br />16. Adding Progesterone helps in the beginning of treatment, but this effect does not last as levels can go too high if left unmonitored at high doses. <br />17. High levels of Progesterone activate hunger and sugar cravings and raise levels of cortisol. <br />18. Rinse and repeat. <br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5271047220330761057.post-44670523568702490562014-07-29T17:40:45.005-07:002014-07-29T17:40:45.005-07:00My pleasure Debbie and yes, your blood can show no...My pleasure Debbie and yes, your blood can show normal or even low estrogen and still be estrogen dominant based on saliva test results.Glen Depke of Depke Wellnesshttps://www.blogger.com/profile/06172459744378973409noreply@blogger.comtag:blogger.com,1999:blog-5271047220330761057.post-85485870245137141412014-07-29T07:04:59.579-07:002014-07-29T07:04:59.579-07:00Thank you for this excellent post. There has alwa...Thank you for this excellent post. There has always been a mystery for me when it comes to hormones. Could someone still be estrogen dominant even if the blood test reveals low estrogen? If it's stored in the fat, I assume this is not showing up in the blood and so I assume that estrogen dominance is still possible. Is that correct? If correct, what test would reveal estrogen dominance for this? Thanks so much!Anonymoushttps://www.blogger.com/profile/13227311849724405424noreply@blogger.com