Is Inflammation Killing You?

by Glen Depke

I know that title is a bit extreme, but you know the old saying, when the shoe fits...

I know, we have been discussing inflammation quite a bit recently but sometimes you come across something so earth shattering that you simply cannot wait to share.

Well, this is one of those shares.

Before we get going, I will provide a brief review the inflammatory process and its affects on the body.

First of all inflammation is a positive response of a healthy immune system but this is without the added triggers and the assumption that all the factors tied into pro and anti-inflammatory processes are working properly. With that said, we can recognize that those with chronic illness generally do not fit in this category.

Most of us fit into the inflammatory process discussed here:

• One of the many triggers that stimulate the receptors that initiate inflammation are present. These are some of the main triggers:
• Mental/emotional stress
• Nutritional stress
• Infections
• Chemotherapy
• Obesity
• Addiction
• ...and more
• The receptors initiate an NF-kB state which is a chronic inflammatory state
• This NF-kB state induces an immune system response
• This response can lead to (the more common are bold):
• Cachexia or wasting syndrome which is a loss of weight, muscle atrophy, fatigue, weakness, and significant loss of appetite in someone who is not actively trying to lose weight
• Adipocytes or fat/connective tissue cells that have differentiated and become specialized in the synthesis (manufacture) and storage of fat also known as chronic weight gain
• Anorexia
• Chronic Fatigue
• Depression
• Neuropathic pain
• Anxiety
• Cognitive impairment
• Sleep disorders
• Dellirium
• ...and so much more

For years in my clinics, we have been addressing inflammatory challenges in the following ways:

• Recognizing and removing the triggers that cause the inflammation, whether this be stress, nutritional, infection, obesity, addiction or other
• Supporting adrenal function to allow proper production of the body's natural anti-inflammatory which is cortisol
• Utilizing anti-inflammatory supplements such as omega 3 fatty acids as well as metabolic enzymes

While this and other factors provided a significant benefit for many clients over the years, there has still been that select few that are finding themselves extremely frustrated. These are the clients that are doing everything correct and still find themselves suffering the pain and discomfort of chronic inflammatory states.

Here's the kicker that is a new found knowledge for me.

While I have always know about chronic inflammatory states, better know in the industry as NF-kB states, what I did not realize is the feedback loops that these states create within themselves. Once you are in this chronic inflammatory state, the NF-kB has the ability to basically feed itself even if you remove all the triggers and basically do everything correctly.

There are feedback loops easily tied into weight gain, gut challenges, immune dysregulation, immune cell activation, poor liver function and so much more. Remember, these feedback loops often continue even if you are doing everything correctly and eliminate all your triggers.

OK, so what's a person to do with these chronic NF-kB states. 

First of all it is still very important to eliminate as many of the triggers as possible and create some balance within your adrenal function. From here it is important to use the best available products to push yourself out of the feedback loops of the NF-kB state.

All the research points to two key ingredients to do the job. Those ingredients are curcumin and resveratrol. The resveratrol is such a powerful component within this cycle that drug companies are racing to create a synthetic to this compound so they can charge you and your insurance company the big bucks for what you can use right now for such a small cost.

Don't go running to the store though to pick these up in capsules. 

While there may be a benefit for a select few of you, many that are deep in this state need something more potent that the capsules. There is a company that produces a emulsified liquid version of both the curcumin and resveratrol that is 4 - 6 times more potent than the capsule and understand that taking the combination of these together severely amplify the suppression of the NF-kB state.

Unfortunately this company does not allow me to sell these over the Internet, so there would have to be direct contact with Depke Wellness. If you would like to discuss the inflammatory programs used by Depke Wellness to stop the NF-kB state, you can call the office direct at 949.954.6226. We work with clients in office as well as via phone consultations.

With all this said, can you now understand the title, "Is Inflammation Killing You?"

If you have any comments or questions in regard to this article feel free to post these below for me to answer personally.

Is Inflammation Good or Bad?

by Glen Depke

I continually hear people talk about inflammation like it is a disease. If you are wondering this yourself, I want you to know right now that it is not. The reality of inflammation is that it is a part of the healing crisis that is leading you to wellness, as long as your body has the strength and balance to complete this healing process.

I was explaining to a client in my office the other day, how happy I am that both of my knees were inflamed. I shared that I was a weekend warrior and played in a game of flag football. My 46 year old knees that have had many other challenges in the past were pushed to a point of stress and damage. Thankfully my bodily processes created inflammation as a response to this damage and my knees are on their way to recovery in the healing crisis.

Let’s briefly discuss the different types of bodily inflammation.

It is first important to understand the different types of inflammation. There is acute inflammation that is the initial response to injury. There is the immune system response that occurs when cells of the immune system are activated in response to the antigens released during acute or chronic stages of inflammation. We then have chronic inflammation which involves the release of interleukins 1, 2 and 3. Over the years with my clients, I find that this chronic inflammatory response is activated by severe stress or alcohol abuse. Stress is such a significant challenge in this chronic inflammatory response.

What should you do with inflammation? It is first helpful to understand what type of inflammation you are dealing with.

If you have acute inflammation the one choice you can make that is a substantial benefit is to soak that area in cold water. For my knees, I fill a bath with the coldest water possible and I sit in this for 20 minutes. I know you may be thinking that you could not possibly deal with the cold water, but after about 30 seconds your body adapts to the temperature and you will gain comfort even in the cold water. I recommend cold water vs. icing the inflamed area because ice can stop the healing crisis without restoration of the tissue in the area. Understand that you do not want to remove acute inflammation; you want to assist your body in moving through the process.

From a supplemental aspect; during acute inflammation I often suggest a homeopathic from Germany called AB No. 11. The indication of use for this is any inflammation that is not accompanied by fever. This is not a cure for inflammation, this is simply another way to assist in your bodies healing crisis. In my mind, a must for any inflammatory response is the use of enteric coated proteolytic enzymes. The one I use in my office is another German product called Marcozymes. These enzymes are designed to survive the acid bath of the stomach with eventual breakdown in the more alkaline environment in the small intestines. From here they will be released in our blood where the enzymes can control inflammation by breaking up inflammatory debris and initiate tissue restitution. If you are looking for rapid healing, proteolytic enzyme use is remarkably effective. It is important to note that these special enzymes are to be taken away from meal time or just before bed. I cannot talk about supplements without also mentioning the benefit of omega 3 fatty acids such as fish oils to aid in the inflammatory response. The omega 3 supplement that we use in our household that I also recommend to my clients is krill oil.

Recognize that the immune response inflammation can be a part of the acute or chronic stage of inflammation. If this is due to the acute response I would recommend the same as above. If the inflammation is long term and the underlying cause of the inflammation is not resolved you may also want to support your immune function. You could review last week’s post, “It’s Cold and Flu Season” to get further information on supporting your immune system function.

Once you get into the chronic inflammatory response, I often find this to be tied into adrenal function. Understand that your body’s natural anti-inflammatory is the hormone cortisone. Cortisone is not a stand-alone hormone and is actually converted from the hormone cortisol. Yes, this is the same hormone we produce when we are under mental, emotional or physical stress. Due to poor functioning adrenal glands, many individuals to not have proper bodily function to initiate the body’s pro and anti-inflammatory response. At this point it is of utmost importance to assess your adrenal function and create the balance needed for your adrenals to do their job. To address this adrenal function you could call our office at 949.642.2094, to schedule a complimentary phone consult to understand adrenal insufficiency. You can also click through the links on our website to gather further information.

There are many other herbs and supplements used to assist with inflammation but this is what I see work consistently in my office with my clients.

Follow these tips to deal with any inflammatory response but most importantly recognize that inflammation is very positive for your body, when your healing crisis is allowed to initiate and finish the job.

If you have any questions or comments please post these below and I will answer them personally.